Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2

Polycomb repressive complex 2 (PRC2) is a key chromatin modifier responsible for methylation of lysine 27 in histone H3. PRC2 has been shown to interact with thousands of RNA species in vivo, but understanding the physiological function of RNA binding has been hampered by the lack of separation-of-f...

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Udgivet i:eLife
Main Authors: Long, Yicheng, Bolanos, Ben, Gong, Lihu, Liu, Wei, Goodrich, Karen J, Yang, Xin, Chen, Siming, Gooding, Anne R, Maegley, Karen A, Gajiwala, Ketan S, Brooun, Alexei, Cech, Thomas R, Liu, Xin
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Biochemistry and Chemical Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706960/
https://ncbi.nlm.nih.gov/pubmed/29185984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31558
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