Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2

Polycomb repressive complex 2 (PRC2) is a key chromatin modifier responsible for methylation of lysine 27 in histone H3. PRC2 has been shown to interact with thousands of RNA species in vivo, but understanding the physiological function of RNA binding has been hampered by the lack of separation-of-f...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Long, Yicheng, Bolanos, Ben, Gong, Lihu, Liu, Wei, Goodrich, Karen J, Yang, Xin, Chen, Siming, Gooding, Anne R, Maegley, Karen A, Gajiwala, Ketan S, Brooun, Alexei, Cech, Thomas R, Liu, Xin
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2017
Teme:
Biochemistry and Chemical Biology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706960/
https://ncbi.nlm.nih.gov/pubmed/29185984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31558
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