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The polycomb proteins EZH1 and EZH2 co-regulate chromatin accessibility and nephron progenitor cell lifespan in mice

SIX2 (SIX homeobox 2)–positive nephron progenitor cells (NPCs) give rise to all epithelial cell types of the nephron, the filtering unit of the kidney. NPCs have a limited lifespan and are depleted near the time of birth. Epigenetic factors are implicated in the maintenance of organ-restricted proge...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Liu, Hongbing, Hilliard, Sylvia, Kelly, Elizabeth, Chen, Chao-Hui, Saifudeen, Zubaida, El-Dahr, Samir S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450110/
https://ncbi.nlm.nih.gov/pubmed/32554463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013348
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