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Mechanisms of p53 activation and physiological relevance in the developing kidney
The tumor suppressor protein p53 is a short-lived transcription factor due to Mdm2-mediated proteosomal degradation. In response to genotoxic stress, p53 is stabilized via posttranslational modifications which prevent Mdm2 binding. p53 activation results in cell cycle arrest and apoptosis. We previo...
में बचाया:
| मुख्य लेखकों: | , , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
American Physiological Society
2012
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3330719/ https://ncbi.nlm.nih.gov/pubmed/22237799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00642.2011 |
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