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Mechanisms of p53 activation and physiological relevance in the developing kidney
The tumor suppressor protein p53 is a short-lived transcription factor due to Mdm2-mediated proteosomal degradation. In response to genotoxic stress, p53 is stabilized via posttranslational modifications which prevent Mdm2 binding. p53 activation results in cell cycle arrest and apoptosis. We previo...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3330719/ https://ncbi.nlm.nih.gov/pubmed/22237799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00642.2011 |
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