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Regulation of kidney development by the Mdm2/Mdm4–p53 axis
While p53 activity is required for tumour suppression, unconstrained p53 activity on the other hand is detrimental to the organism, resulting in inappropriate cellular death or proliferation defects. Unimpeded p53 activity is lethal in the developing embryo, underlining the need for maintaining a ti...
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| Опубликовано в: : | J Mol Cell Biol |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5907835/ https://ncbi.nlm.nih.gov/pubmed/28096292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjx005 |
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