The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis

EphB4 and its cognitive ligand ephrinB2 play an important role in embryonic vessel development and vascular remodeling. In addition, several reports suggest that this receptor ligand pair is also involved in pathologic vessel formation in adults including tumor angiogenesis. Eph/ephrin signaling is...

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Detalhes bibliográficos
Main Authors: Martiny-Baron, Georg, Holzer, Philipp, Billy, Eric, Schnell, Christian, Brueggen, Joseph, Ferretti, Mireille, Schmiedeberg, Niko, Wood, Jeanette M., Furet, Pascal, Imbach, Patricia
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2010
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941628/
https://ncbi.nlm.nih.gov/pubmed/20803239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10456-010-9183-z
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