The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study

Paclitaxel exhibits clinical activity against a wide variety of solid tumors. However, resistance to paclitaxel significantly attenuates the response to chemotherapy. The ABC transporter subfamily C member 10 (ABCC10), also known as multi-drug resistance protein 7 (MRP7) efflux transporter, is a maj...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kathawala, Rishil J., Wei, Liuya, Anreddy, Nagaraju, Chen, Kang, Patel, Atish, Alqahtani, Saeed, Zhang, Yun-Kai, Wang, Yi-Jun, Sodani, Kamlesh, Kaddoumi, Amal, Ashby, Charles R., Chen, Zhe-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381611/
https://ncbi.nlm.nih.gov/pubmed/25402202
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