Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes

p53 tumor suppressor activity is negatively regulated through binding to the oncogenic proteins Hdm2 and HdmX. The p53 residues Leu(26), Trp(23), and Phe(19) are crucial to mediate these interactions. Inhibiting p53 binding to both Hdm2 and HdmX should be a promising clinical approach to reactivate...

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Detalhes bibliográficos
Main Authors: Kallen, Joerg, Goepfert, Arnaud, Blechschmidt, Anke, Izaac, Aude, Geiser, Martin, Tavares, Gisele, Ramage, Paul, Furet, Pascal, Masuya, Keiichi, Lisztwan, Joanna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659239/
https://ncbi.nlm.nih.gov/pubmed/19153082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809096200
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