Preclinical Development of PQR514, a Highly Potent PI3K Inhibitor Bearing a Difluoromethyl–Pyrimidine Moiety

[Image: see text] The phosphoinositide 3-kinase (PI3K)/mechanistic target of rapamycin (mTOR) pathway is a critical regulator of cell growth and is frequently hyperactivated in cancer. Therefore, PI3K inhibitors represent a valuable asset in cancer therapy. Herein we have developed a novel anticance...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Borsari, Chiara, Rageot, Denise, Beaufils, Florent, Bohnacker, Thomas, Keles, Erhan, Buslov, Ivan, Melone, Anna, Sele, Alexander M., Hebeisen, Paul, Fabbro, Doriano, Hillmann, Petra, Wymann, Matthias P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792169/
https://ncbi.nlm.nih.gov/pubmed/31620236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00333
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