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Kinase Inhibition by Deoxy Analogues of the Resorcylic Lactone L-783277

[Image: see text] The natural product L-783277 is a resorcylic lactone type covalent kinase inhibitor. We have prepared the 5′-deoxy analogue of L-783277 (1) in a stereoselective fashion. Remarkably, this analogue retains almost the full kinase inhibitory potential of natural L-783277, with low nano...

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Detalhes bibliográficos
Main Authors: Liniger, Marc, Neuhaus, Christian, Hofmann, Tatjana, Fransioli-Ignazio, Luca, Jordi, Michel, Drueckes, Peter, Trappe, Jörg, Fabbro, Doriano, Altmann, Karl-Heinz
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018056/
https://ncbi.nlm.nih.gov/pubmed/24900250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1001807
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