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Kinase Inhibition by Deoxy Analogues of the Resorcylic Lactone L-783277
[Image: see text] The natural product L-783277 is a resorcylic lactone type covalent kinase inhibitor. We have prepared the 5′-deoxy analogue of L-783277 (1) in a stereoselective fashion. Remarkably, this analogue retains almost the full kinase inhibitory potential of natural L-783277, with low nano...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4018056/ https://ncbi.nlm.nih.gov/pubmed/24900250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1001807 |
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