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Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors

DYRK1A is a pleiotropic protein kinase with diverse functions in cellular regulation, including cell cycle control, neuronal differentiation, and synaptic transmission. Enhanced activity and overexpression of DYRK1A have been linked to altered brain development and function in Down syndrome and neur...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Rüben, Katharina, Wurzlbauer, Anne, Walte, Agnes, Sippl, Wolfgang, Bracher, Franz, Becker, Walter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4508061/
https://ncbi.nlm.nih.gov/pubmed/26192590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132453
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