Novel Carboline Derivatives as Potent Antifungal Lead Compounds: Design, Synthesis, and Biological Evaluation

[Image: see text] A series of novel antifungal carboline derivatives was designed and synthesized, which showed broad-spectrum antifungal activity. Particularly, compound C38 showed comparable in vitro antifungal activity to fluconazole without toxicity to human embryonic lung cells. It also exhibit...

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Detalhes bibliográficos
Main Authors: Wang, Shengzheng, Wang, Yan, Liu, Wei, Liu, Na, Zhang, Yongqiang, Dong, Guoqiang, Liu, Yang, Li, Zhengang, He, Xiaomeng, Miao, Zhenyuan, Yao, Jianzhong, Li, Jian, Zhang, Wannian, Sheng, Chunquan
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027750/
https://ncbi.nlm.nih.gov/pubmed/24900870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400492t
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