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Structural simplification: an efficient strategy in lead optimization
The trend toward designing large hydrophobic molecules for lead optimization is often associated with poor drug-likeness and high attrition rates in drug discovery and development. Structural simplification is a powerful strategy for improving the efficiency and success rate of drug design by avoidi...
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| Izdano u: | Acta Pharm Sin B |
|---|---|
| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6804494/ https://ncbi.nlm.nih.gov/pubmed/31649841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2019.05.004 |
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