Dual NAMPT/HDAC Inhibitors as a New Strategy for Multitargeting Antitumor Drug Discovery

[Image: see text] Novel dual nicotinamide phosphoribosyltransferase (NAMPT) and histone deacetylase (HDAC) inhibitors were designed by a pharmacophore fusion approach. The thiazolocarboxamide inhibitors were highly active for both targets. In particular, compound 7f (NAMPT IC(50) = 15 nM, HDAC1 IC(5...

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Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Chen, Wei, Dong, Guoqiang, Wu, Ying, Zhang, Wannian, Miao, Chaoyu, Sheng, Chunquan
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2017
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767891/
https://ncbi.nlm.nih.gov/pubmed/29348808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00414
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