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Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors

[Image: see text] In order to take advantage of both immunotherapeutic and epigenetic antitumor agents, the first generation of dual indoleamine 2,3-dioxygenase 1 (IDO1) and histone deacetylase (HDAC) inhibitors were designed. The highly active dual inhibitor 10 showed excellent and balanced activit...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Fang, Kun, Dong, Guoqiang, Li, Yu, He, Shipeng, Wu, Ying, Wu, Shanchao, Wang, Wei, Sheng, Chunquan
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900342/
https://ncbi.nlm.nih.gov/pubmed/29670692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00487
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