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Identification of potent catalytic inhibitors of human DNA topoisomerase II by structure-based virtual screening
Human DNA topoisomerase II (Top2) is a promising target for cancer treatment. To overcome the limitations of known Top2 inhibitors, novel Top2 catalytic inhibitors with new scaffolds were identified by structure-based virtual screening. In particular, compound 8 showed good in vitro antiproliferativ...
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| Publicado no: | Medchemcomm |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6071756/ https://ncbi.nlm.nih.gov/pubmed/30109001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00219c |
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