Discovery of Novel Multiacting Topoisomerase I/II and Histone Deacetylase Inhibitors

[Image: see text] Designing multitarget drugs remains a significant challenge in current antitumor drug discovery. Because of the synergistic effect between topoisomerase and HDAC inhibitors, the present study reported the first-in-class triple inhibitors of topoisomerase I/II and HDAC. On the basis...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: He, Shipeng, Dong, Guoqiang, Wang, Zhibin, Chen, Wei, Huang, Yahui, Li, Zhengang, Jiang, Yan, Liu, Na, Yao, Jianzhong, Miao, Zhenyuan, Zhang, Wannian, Sheng, Chunquan
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360171/
https://ncbi.nlm.nih.gov/pubmed/25815139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500327q
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