A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug–Drug–Gene Interaction Predictions

অনুযায়ী Türk, Denise, Hanke, Nina, Lehr, Thorsten
প্রকাশিত Pharmaceutics (2020)

A Quantitative Systems Pharmacology Kidney Model of Diabetes Associated Renal Hyperfiltration and the Effects of SGLT Inhibitors

অনুযায়ী Balazki, Pavel, Schaller, Stephan, Eissing, Thomas, Lehr, Thorsten
প্রকাশিত CPT Pharmacometrics Syst Pharmacol (2018)

A Physiologically‐Based Quantitative Systems Pharmacology Model of the Incretin Hormones GLP‐1 and GIP and the DPP4 Inhibitor Sitagliptin

অনুযায়ী Balazki, Pavel, Schaller, Stephan, Eissing, Thomas, Lehr, Thorsten
প্রকাশিত CPT Pharmacometrics Syst Pharmacol (2020)

Effective Removal of Dabigatran by Idarucizumab or Hemodialysis: A Physiologically Based Pharmacokinetic Modeling Analysis

অনুযায়ী Fuhr, Laura Maria, Hanke, Nina, Meibohm, Bernd, Lehr, Thorsten
প্রকাশিত Clin Pharmacokinet (2020)

ATIM-13. ASUNERCEPT PLUS RADIOTHERAPY IN RELAPSED GLIOBLASTOMA. UPDATE ON FIVE YEARS OVERALL SURVIVAL OF STUDY NCT01071837 AND DEVELOPMENT OF A POPULATION-PK - TUMOR GROWTH INHIBIT...

অনুযায়ী Ficke, Harald, Hanke, Nina, Kunz, Claudia, Wick, Wolfgang, Lehr, Thorsten
প্রকাশিত Neuro Oncol (2018)

Translational PBPK Modeling of the Protein Therapeutic and CD95L Inhibitor Asunercept to Develop Dose Recommendations for Its First Use in Pediatric Glioblastoma Patients

অনুযায়ী Hanke, Nina, Kunz, Claudia, Thiemann, Meinolf, Fricke, Harald, Lehr, Thorsten
প্রকাশিত Pharmaceutics (2019)

Quantitative Pharmacology Approach in Alzheimer’s Disease: Efficacy Modeling of Early Clinical Data to Predict Clinical Outcome of Tesofensine

অনুযায়ী Lehr, Thorsten, Staab, Alexander, Trommeshauser, Dirk, Schaefer, Hans Guenter, Kloft, Charlotte
প্রকাশিত 2010

Rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies

অনুযায়ী Lehr, Thorsten, Yuan, Jing, Zeumer, Dirk, Jayadev, Supriya, Ritchie, Marylyn D
প্রকাশিত 2011

Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling

অনুযায়ী Wojtyniak, Jan‐Georg, Britz, Hannah, Selzer, Dominik, Schwab, Matthias, Lehr, Thorsten
প্রকাশিত CPT Pharmacometrics Syst Pharmacol (2020)

Neovascular Age‐Related Macular Degeneration: A Visual Acuity Model of Natural Disease Progression and Ranibizumab Treatment Effect

অনুযায়ী Mulyukov, Zufar, Weber, Sebastian, Pigeolet, Etienne, Clemens, Andreas, Lehr, Thorsten, Racine, Amy
প্রকাশিত CPT Pharmacometrics Syst Pharmacol (2018)

Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug–Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach

অনুযায়ী Fuhr, Laura Maria, Marok, Fatima Zahra, Hanke, Nina, Selzer, Dominik, Lehr, Thorsten
প্রকাশিত Pharmaceutics (2021)

Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network

অনুযায়ী Marok, Fatima Zahra, Fuhr, Laura Maria, Hanke, Nina, Selzer, Dominik, Lehr, Thorsten
প্রকাশিত Pharmaceutics (2021)

Pharmacometric Characterization of Dabigatran Hemodialysis

অনুযায়ী Liesenfeld, Karl-Heinz, Staab, Alexander, Härtter, Sebastian, Formella, Stephan, Clemens, Andreas, Lehr, Thorsten
প্রকাশিত 2013

MDM2 antagonist nutlin‐3a sensitizes tumors to V‐ATPase inhibition

অনুযায়ী Schneider, Lina S., Ulrich, Melanie, Lehr, Thorsten, Menche, Dirk, Müller, Rolf, von Schwarzenberg, Karin
প্রকাশিত Mol Oncol (2016)

PBPK Models for CYP3A4 and P‐gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin

অনুযায়ী Hanke, Nina, Frechen, Sebastian, Moj, Daniel, Britz, Hannah, Eissing, Thomas, Wendl, Thomas, Lehr, Thorsten
প্রকাশিত CPT Pharmacometrics Syst Pharmacol (2018)

Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates

অনুযায়ী Kovar, Lukas, Schräpel, Christina, Selzer, Dominik, Kohl, Yvonne, Bals, Robert, Schwab, Matthias, Lehr, Thorsten
প্রকাশিত Pharmaceutics (2020)

Population pharmacokinetic modelling of NS2330 (tesofensine) and its major metabolite in patients with Alzheimer's disease

অনুযায়ী Lehr, Thorsten, Staab, Alexander, Tillmann, Christiane, Trommeshauser, Dirk, Raschig, Andreas, Schaefer, Hans Guenter, Kloft, Charlotte
প্রকাশিত 2007

Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and α-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions

অনুযায়ী Rüdesheim, Simeon, Wojtyniak, Jan-Georg, Selzer, Dominik, Hanke, Nina, Mahfoud, Felix, Schwab, Matthias, Lehr, Thorsten
প্রকাশিত Pharmaceutics (2020)

A physiologically-based pharmacokinetic and pharmacodynamic (PBPK/PD) model of the histone deacetylase (HDAC) inhibitor vorinostat for pediatric and adult patients and its applicat...

অনুযায়ী Moj, Daniel, Britz, Hannah, Burhenne, Jürgen, Stewart, Clinton F., Egerer, Gerlinde, Haefeli, Walter E., Lehr, Thorsten
প্রকাশিত Cancer Chemother Pharmacol (2017)

Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug–Drug–Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pio...

অনুযায়ী Türk, Denise, Hanke, Nina, Wolf, Sarah, Frechen, Sebastian, Eissing, Thomas, Wendl, Thomas, Schwab, Matthias, Lehr, Thorsten
প্রকাশিত Clin Pharmacokinet (2019)