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A physiologically-based pharmacokinetic and pharmacodynamic (PBPK/PD) model of the histone deacetylase (HDAC) inhibitor vorinostat for pediatric and adult patients and its application for dose specification
PURPOSE: This study aimed at recommending pediatric dosages of the histone deacetylase (HDAC) inhibitor vorinostat and potentially more effective adult dosing regimens than the approved standard dosing regimen of 400 mg/day, using a comprehensive physiologically-based pharmacokinetic/pharmacodynamic...
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| Publicado no: | Cancer Chemother Pharmacol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6056765/ https://ncbi.nlm.nih.gov/pubmed/28988277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-017-3447-x |
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