Comprehensive Parent–Metabolite PBPK/PD Modeling Insights into Nicotine Replacement Therapy Strategies

BACKGROUND: Nicotine, the pharmacologically active substance in both tobacco and many electronic cigarette (e-cigarette) liquids, is responsible for the addiction that sustains cigarette smoking. With 8 million deaths worldwide annually, smoking remains one of the major causes of disability and prem...

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Bibliografiske detaljer
Udgivet i:Clin Pharmacokinet
Main Authors: Kovar, Lukas, Selzer, Dominik, Britz, Hannah, Benowitz, Neal, St. Helen, Gideon, Kohl, Yvonne, Bals, Robert, Lehr, Thorsten
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2020
Fag:
Original Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7467963/
https://ncbi.nlm.nih.gov/pubmed/32166575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-020-00880-4
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