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Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients

Fentanyl is widely used for analgesia, sedation, and anesthesia both in adult and pediatric populations. Yet, only few pharmacokinetic studies of fentanyl in pediatrics exist as conducting clinical trials in this population is especially challenging. Physiologically-based pharmacokinetic (PBPK) mode...

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Vydáno v:Pharmaceutics
Hlavní autoři: Kovar, Lukas, Weber, Andreas, Zemlin, Michael, Kohl, Yvonne, Bals, Robert, Meibohm, Bernd, Selzer, Dominik, Lehr, Thorsten
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598194/
https://ncbi.nlm.nih.gov/pubmed/32977559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12100908
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