Applying (89)Zr-Transferrin To Study the Pharmacology of Inhibitors to BET Bromodomain Containing Proteins

[Image: see text] Chromatin modifying proteins are attractive drug targets in oncology, given the fundamental reliance of cancer on altered transcriptional activity. Multiple transcription factors can be impacted downstream of primary target inhibition, thus making it challenging to understand the d...

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Détails bibliographiques
Publié dans:Mol Pharm
Auteurs principaux: Doran, Michael G., Carnazza, Kathryn E., Steckler, Jeffrey M., Spratt, Daniel E., Truillet, Charles, Wongvipat, John, Sawyers, Charles L., Lewis, Jason S., Evans, Michael J.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2016
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738321/
https://ncbi.nlm.nih.gov/pubmed/26725682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00882
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