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Non-invasive measurement of mTORC1 signaling with (89)Zr-transferrin

PURPOSE: mTOR regulates many normal physiological processes and when hyperactive, can drive numerous cancers and human diseases. However, it is very challenging to detect and quantify mTOR signaling non-invasively in clinically relevant animal models of disease or man. We hypothesized that a nuclear...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Truillet, Charles, Cunningham, John T., Parker, Matthew F.L., Huynh, Loc T., Conn, Crystal S., Ruggero, Davide, Lewis, Jason S., Evans, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474159/
https://ncbi.nlm.nih.gov/pubmed/28007777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2448
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