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Targeting MYC dependence in cancer by inhibiting BET bromodomains
The MYC transcription factor is a master regulator of diverse cellular functions and has been long considered a compelling therapeutic target because of its role in a range of human malignancies. However, pharmacologic inhibition of MYC function has proven challenging because of both the diverse mec...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3189078/ https://ncbi.nlm.nih.gov/pubmed/21949397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108190108 |
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