Targeting MYC dependence in cancer by inhibiting BET bromodomains

The MYC transcription factor is a master regulator of diverse cellular functions and has been long considered a compelling therapeutic target because of its role in a range of human malignancies. However, pharmacologic inhibition of MYC function has proven challenging because of both the diverse mec...

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Detaylı Bibliyografya
Asıl Yazarlar: Mertz, Jennifer A., Conery, Andrew R., Bryant, Barbara M., Sandy, Peter, Balasubramanian, Srividya, Mele, Deanna A., Bergeron, Louise, Sims, Robert J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189078/
https://ncbi.nlm.nih.gov/pubmed/21949397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108190108
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