An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition

Chromatin immunoprecipitation and DNA sequencing (ChIP-seq) has been instrumental in inferring the roles of histone post-translational modifications in the regulation of transcription, chromatin compaction and other cellular processes that require modulation of chromatin structure. However, analysis...

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Veröffentlicht in:PLoS One
Hauptverfasser: Egan, Brian, Yuan, Chih-Chi, Craske, Madeleine Lisa, Labhart, Paul, Guler, Gulfem D., Arnott, David, Maile, Tobias M., Busby, Jennifer, Henry, Chisato, Kelly, Theresa K., Tindell, Charles A., Jhunjhunwala, Suchit, Zhao, Feng, Hatton, Charlie, Bryant, Barbara M., Classon, Marie, Trojer, Patrick
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119738/
https://ncbi.nlm.nih.gov/pubmed/27875550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166438
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