Potent and Selective α-Ketoheterocycle-Based Inhibitors of the Anandamide and Oleamide Catabolizing Enzyme, Fatty Acid Amide Hydrolase

A study of the structure–activity relationships (SAR) of 2f (OL-135), a potent inhibitor of fatty acid amide hydrolase (FAAH), is detailed targeting the 5-position of the oxazole. Examination of a series of substituted benzene derivatives (12–14) revealed that the optimal position for substitution w...

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Autores principales: Romero, F. Anthony, Du, Wu, Hwang, Inkyu, Rayl, Thomas J., Kimball, F. Scott, Leung, Donmienne, Hoover, Heather S., Apodaca, Richard L., Breitenbucher, J. Guy, Cravatt, Benjamin F., Boger, Dale L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2531193/
https://ncbi.nlm.nih.gov/pubmed/17279740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0611509
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