Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide

The development of exceptionally potent inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for the degradation of oleamide (an endogenous sleep-inducing lipid), and anandamide (an endogenous ligand for cannabinoid receptors) is detailed. The inhibitors may serve as useful tools...

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Detalhes bibliográficos
Main Authors: Boger, Dale L., Sato, Haruhiko, Lerner, Aaron E., Hedrick, Michael P., Fecik, Robert A., Miyauchi, Hiroshi, Wilkie, Gordon D., Austin, Bryce J., Patricelli, Matthew P., Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC25778/
https://ncbi.nlm.nih.gov/pubmed/10805767
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