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Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide

The development of exceptionally potent inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for the degradation of oleamide (an endogenous sleep-inducing lipid), and anandamide (an endogenous ligand for cannabinoid receptors) is detailed. The inhibitors may serve as useful tools...

Deskribapen osoa

Gorde:
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Boger, Dale L., Sato, Haruhiko, Lerner, Aaron E., Hedrick, Michael P., Fecik, Robert A., Miyauchi, Hiroshi, Wilkie, Gordon D., Austin, Bryce J., Patricelli, Matthew P., Cravatt, Benjamin F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2000
Gaiak:
Physical Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25778/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10805767/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.10.5044
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