Exploration of a fundamental substituent effect of α-ketoheterocycle enzyme inhibitors: potent and selective inhibitors of fatty acid amide hydrolase

A series of C4 substituted α-ketooxazoles were examined as inhibitors of the serine hydrolase fatty acid amide hydrolase in efforts that further define and generalize a fundamental substituent effect on enzyme inhibitory potency. Thus, a plot of the Hammett σ(m) versus –log K(i) provided a linear co...

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Hauptverfasser: DeMartino, Jessica K., Garfunkle, Joie, Hochstatter, Dustin G., Cravatt, Benjamin F., Boger, Dale L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582052/
https://ncbi.nlm.nih.gov/pubmed/18639454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.06.084
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