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α-Ketoheterocycle-Based Inhibitors of Fatty Acid Amide Hydrolase (FAAH)

[Image: see text] A summary of the initial discovery and characterization of the enzyme fatty acid amide hydrolase (FAAH), and the subsequent advancement of an important class of competitive, reversible, potent, and selective inhibitors is presented. Initially explored using substrate-inspired inhib...

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Detalhes bibliográficos
Main Authors: Otrubova, Katerina, Boger, Dale L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359644/
https://ncbi.nlm.nih.gov/pubmed/22639704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn2001206
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