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α-Ketoheterocycle-Based Inhibitors of Fatty Acid Amide Hydrolase (FAAH)

[Image: see text] A summary of the initial discovery and characterization of the enzyme fatty acid amide hydrolase (FAAH), and the subsequent advancement of an important class of competitive, reversible, potent, and selective inhibitors is presented. Initially explored using substrate-inspired inhib...

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Autors principals: Otrubova, Katerina, Boger, Dale L.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2011
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359644/
https://ncbi.nlm.nih.gov/pubmed/22639704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn2001206
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