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α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase: Exploration of Conformational Constraints in the Acyl Side Chain

[Image: see text] A series of α-ketooxazoles containing heteroatoms embedded within conformational constraints in the C2 acyl side chain of 2 (OL-135) were synthesized and evaluated as inhibitors of fatty acid amide hydrolase (FAAH). The studies reveal that the installation of a heteroatom (O) in th...

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Bibliografiske detaljer
Main Authors: Duncan, Katharine K., Otrubova, Katerina, Boger, Dale L.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029506/
https://ncbi.nlm.nih.gov/pubmed/24690529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.03.013
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