Reversible Competitive α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long Acting Analgesics

A series of α-ketooxazoles containing conformational constraints in the C2 acyl side chain of 2 (OL-135) were examined as inhibitors of fatty acid amide hydrolase (FAAH). Only one of the two possible enantiomers displayed potent FAAH inhibition (S vs R enantiomer), and their potency is comparable or...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Ezzili, Cyrine, Mileni, Mauro, McGlinchey, Nicholas, Long, Jonathan Z., Kinsey, Steven G., Hochstatter, Dustin G., Stevens, Raymond C., Lichtman, Aron H., Cravatt, Benjamin F., Bilsky, Edward J., Boger, Dale L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085948/
https://ncbi.nlm.nih.gov/pubmed/21428410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101597x
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados