Structure–Activity Relationships of α-Keto Oxazole Inhibitors of Fatty Acid Amide Hydrolase

A systematic study of the structure–activity relationships (SAR) of 2b (OL-135), a potent inhibitor of fatty acid amide hydrolase (FAAH), is detailed targeting the C2 acyl side chain. A series of aryl replacements or substituents for the terminal phenyl group provided effective inhibitors (e.g., 5c,...

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Detalhes bibliográficos
Main Authors: Hardouin, Christophe, Kelso, Michael J., Romero, F. Anthony, Rayl, Thomas J., Leung, Donmienne, Hwang, Inkyu, Cravatt, Benjamin F., Boger, Dale L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2531194/
https://ncbi.nlm.nih.gov/pubmed/17559203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm061414r
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