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Optimization of α-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase
A series of α-ketooxazoles containing conformational constraints in the flexible C2 acyl side chain of 2 (OL-135) and representative oxazole C5 substituents was prepared and examined as inhibitors of fatty acid amide hydrolase (FAAH). Exceptionally potent and selective FAAH inhibitors emerged from t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2734917/ https://ncbi.nlm.nih.gov/pubmed/18247553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm701210y |
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