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Optimization of α-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase

A series of α-ketooxazoles containing conformational constraints in the flexible C2 acyl side chain of 2 (OL-135) and representative oxazole C5 substituents was prepared and examined as inhibitors of fatty acid amide hydrolase (FAAH). Exceptionally potent and selective FAAH inhibitors emerged from t...

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Autors principals: Kimball, F. Scott, Romero, F. Anthony, Ezzili, Cyrine, Garfunkle, Joie, Rayl, Thomas J., Hochstatter, Dustin G., Hwang, Inkyu, Boger, Dale L.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734917/
https://ncbi.nlm.nih.gov/pubmed/18247553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm701210y
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