To be or not to be a piRNA: genomic origin and processing of piRNAs

von Le Thomas, Adrien, Tóth, Katalin Fejes, Aravin, Alexei A
Veröffentlicht 2014

A trans-generational process defines piRNA biogenesis in Drosophila virilis

von Le Thomas, Adrien, Marinov, Georgi K., Aravin, Alexei A.
Veröffentlicht in Cell Rep (2014)

Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state

von Le Thomas, Adrien, Rogers, Alicia K., Webster, Alexandre, Marinov, Georgi K., Liao, Susan E., Perkins, Edward M., Hur, Junho K., Aravin, Alexei A., Tóth, Katalin Fejes
Veröffentlicht 2013

Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing

von Le Thomas, Adrien, Stuwe, Evelyn, Li, Sisi, Du, Jiamu, Marinov, Georgi, Rozhkov, Nikolay, Chen, Yung-Chia Ariel, Luo, Yicheng, Sachidanandam, Ravi, Toth, Katalin Fejes, Patel, Dinshaw, Aravin, Alexei A.
Veröffentlicht 2014

Cutoff suppresses RNA polymerase II termination to ensure expression of piRNA precursors

von Chen, Yung-Chia Ariel, Stuwe, Evelyn, Luo, Yicheng, Ninova, Maria, Le Thomas, Adrien, Rozhavskaya, Ekaterina, Li, Sisi, Vempati, Sivani, Laver, John D., Patel, Dinshaw J., Smibert, Craig A., Lipshitz, Howard D., Toth, Katalin Fejes, Aravin, Alexei A.
Veröffentlicht in Mol Cell (2016)

Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands

von Ferri, Elena, Le Thomas, Adrien, Wallweber, Heidi Ackerly, Day, Eric S., Walters, Benjamin T., Kaufman, Susan E., Braun, Marie-Gabrielle, Clark, Kevin R., Beresini, Maureen H., Mortara, Kyle, Chen, Yung-Chia A., Canter, Breanna, Phung, Wilson, Liu, Peter S., Lammens, Alfred, Ashkenazi, Avi, Rudolph, Joachim, Wang, Weiru
Veröffentlicht in Nat Commun (2020)

IRE1α disruption in triple-negative breast cancer cooperates with anti-angiogenic therapy by reversing ER stress adaptation and remodeling the tumor microenvironment

von Harnoss, Jonathan M, Le Thomas, Adrien, Reichelt, Mike, Guttman, Ofer, Wu, Thomas D, Marsters, Scot A, Shemorry, Anna, Lawrence, David A, Kan, David, Segal, Ehud, Merchant, Mark, Totpal, Klara, Crocker, Lisa M, Mesh, Kathryn, Dohse, Monika, Solon, Margaret, Modrusan, Zora, Rudolph, Joachim, Koeppen, Hartmut, Walter, Peter, Ashkenazi, Avi
Veröffentlicht in Cancer Res (2020)

Disruption of IRE1α through its kinase domain attenuates multiple myeloma

von Harnoss, Jonathan M., Le Thomas, Adrien, Shemorry, Anna, Marsters, Scot A., Lawrence, David A., Lu, Min, Chen, Yung-Chia Ariel, Qing, Jing, Totpal, Klara, Kan, David, Segal, Ehud, Merchant, Mark, Reichelt, Mike, Ackerly Wallweber, Heidi, Wang, Weiru, Clark, Kevin, Kaufman, Susan, Beresini, Maureen H., Laing, Steven T., Sandoval, Wendy, Lorenzo, Maria, Wu, Jiansheng, Ly, Justin, De Bruyn, Tom, Heidersbach, Amy, Haley, Benjamin, Gogineni, Alvin, Weimer, Robby M., Lee, Dong, Braun, Marie-Gabrielle, Rudolph, Joachim, VanWyngarden, Michael J., Sherbenou, Daniel W., Gomez-Bougie, Patricia, Amiot, Martine, Acosta-Alvear, Diego, Walter, Peter, Ashkenazi, Avi
Veröffentlicht in Proc Natl Acad Sci U S A (2019)