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Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state
In the metazoan germline, piwi proteins and associated piwi-interacting RNAs (piRNAs) provide a defense system against the expression of transposable elements. In the cytoplasm, piRNA sequences guide piwi complexes to destroy complementary transposon transcripts by endonucleolytic cleavage. However,...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cold Spring Harbor Laboratory Press
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3589556/ https://ncbi.nlm.nih.gov/pubmed/23392610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.209841.112 |
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