Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state

In the metazoan germline, piwi proteins and associated piwi-interacting RNAs (piRNAs) provide a defense system against the expression of transposable elements. In the cytoplasm, piRNA sequences guide piwi complexes to destroy complementary transposon transcripts by endonucleolytic cleavage. However,...

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Bibliografiske detaljer
Main Authors: Le Thomas, Adrien, Rogers, Alicia K., Webster, Alexandre, Marinov, Georgi K., Liao, Susan E., Perkins, Edward M., Hur, Junho K., Aravin, Alexei A., Tóth, Katalin Fejes
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2013
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589556/
https://ncbi.nlm.nih.gov/pubmed/23392610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.209841.112
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