Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing

Small noncoding RNAs that associate with Piwi proteins, called piRNAs, serve as guides for repression of diverse transposable elements in germ cells of metazoa. In Drosophila, the genomic regions that give rise to piRNAs, the so-called piRNA clusters, are transcribed to generate long precursor molec...

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Main Authors: Le Thomas, Adrien, Stuwe, Evelyn, Li, Sisi, Du, Jiamu, Marinov, Georgi, Rozhkov, Nikolay, Chen, Yung-Chia Ariel, Luo, Yicheng, Sachidanandam, Ravi, Toth, Katalin Fejes, Patel, Dinshaw, Aravin, Alexei A.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2014
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117942/
https://ncbi.nlm.nih.gov/pubmed/25085419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.245514.114
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