Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing

Small noncoding RNAs that associate with Piwi proteins, called piRNAs, serve as guides for repression of diverse transposable elements in germ cells of metazoa. In Drosophila, the genomic regions that give rise to piRNAs, the so-called piRNA clusters, are transcribed to generate long precursor molec...

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Bibliographische Detailangaben
Hauptverfasser: Le Thomas, Adrien, Stuwe, Evelyn, Li, Sisi, Du, Jiamu, Marinov, Georgi, Rozhkov, Nikolay, Chen, Yung-Chia Ariel, Luo, Yicheng, Sachidanandam, Ravi, Toth, Katalin Fejes, Patel, Dinshaw, Aravin, Alexei A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117942/
https://ncbi.nlm.nih.gov/pubmed/25085419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.245514.114
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