Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex

PIWI proteins use guide piRNAs to repress selfish genomic elements, protecting the genomic integrity of gametes and ensuring the fertility of animal species. Efficient transposon repression depends on amplification of piRNA guides in the ping-pong cycle, which in Drosophila entails tight cooperation...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Huang, Xiawei, Hu, Hongmiao, Webster, Alexandre, Zou, Fan, Du, Jiamu, Patel, Dinshaw J., Sachidanandam, Ravi, Toth, Katalin Fejes, Aravin, Alexei A., Li, Sisi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8249470/
https://ncbi.nlm.nih.gov/pubmed/34210982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24351-x
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