A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice

piRNAs and Piwi proteins have been implicated in transposon control and are linked to transposon methylation in mammals. Here, we examined the construction of the piRNA system in the restricted developmental window in which methylation patterns are set during mammalian embryogenesis. We find robust...

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Main Authors: Aravin, Alexei A., Sachidanandam, Ravi, Bourc’his, Deborah, Schaefer, Christopher, Pezic, Dubravka, Fejes Toth, Katalin, Bestor, Timothy, Hannon, Gregory J.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730041/
https://ncbi.nlm.nih.gov/pubmed/18922463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.09.003
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