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piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells

Transposable elements (TEs) occupy a large fraction of metazoan genomes and pose a constant threat to genomic integrity. This threat is particularly critical in germ cells, as changes in the genome that are induced by TEs will be transmitted to the next generation. Small noncoding piwi-interacting R...

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Detalhes bibliográficos
Main Authors: Pezic, Dubravka, Manakov, Sergei A., Sachidanandam, Ravi, Aravin, Alexei A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083086/
https://ncbi.nlm.nih.gov/pubmed/24939875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.240895.114
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