HGF/MET-directed therapeutics in gastroesophageal cancer: a review of clinical and biomarker development

Por Hack, Stephen P., Bruey, Jean-Marie, Koeppen, Hartmut
Publicado em 2014

Selective Expression of Murine Prostate Stem Cell Antigen in Fetal and Adult Tissues and the Transgenic Adenocarcinoma of the Mouse Prostate Model of Prostate Carcinogenesis

Por Ross, Sarajane, Spencer, Susan D., Lasky, Laurence A., Koeppen, Hartmut
Publicado em 2001

p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway

Por Radu, Maria, Lyle, Karen, Hoeflich, Klaus P., Villamar-Cruz, Olga, Koeppen, Hartmut, Chernoff, Jonathan
Publicado no Mol Cell Biol (2015)

MET Suppresses Epithelial VEGFR2 via Intracrine VEGF-induced Endoplasmic Reticulum-associated Degradation

Por Chen, Tom T., Filvaroff, Ellen, Peng, Jing, Marsters, Scot, Jubb, Adrian, Koeppen, Hartmut, Merchant, Mark, Ashkenazi, Avi
Publicado no EBioMedicine (2015)

High CD21 expression inhibits internalization of anti-CD19 antibodies and cytotoxicity of an anti-CD19-drug conjugate

Por Ingle, Gladys S, Chan, Pamela, Elliott, J Michael, Chang, Wesley S, Koeppen, Hartmut, Stephan, Jean-Philippe, Scales, Suzie J
Publicado em 2008

Antigenic Cancer Cells Grow Progressively in Immune Hosts without Evidence for T Cell Exhaustion or Systemic Anergy

Por Wick, Maresa, Dubey, Purnima, Koeppen, Hartmut, Siegel, Christopher T., Fields, Patrick E., Chen, Lieping, Bluestone, Jeffrey A., Schreiber, Hans
Publicado em 1997

High cell-surface density of HER2 deforms cell membranes

Por Chung, Inhee, Reichelt, Mike, Shao, Lily, Akita, Robert W., Koeppen, Hartmut, Rangell, Linda, Schaefer, Gabriele, Mellman, Ira, Sliwkowski, Mark X.
Publicado no Nat Commun (2016)

p21-activated kinase 1: PAK'ed with potential

Por Ong, Christy C., Jubb, Adrian M., Zhou, Wei, Haverty, Peter M., Harris, Adrian L., Belvin, Marcia, Friedman, Lori S., Koeppen, Hartmut, Hoeflich, Klaus P.
Publicado em 2011

CUPLIKE NUCLEI (PROMINENT NUCLEAR INVAGINATIONS) IN ACUTE MYELOID LEUKEMIA ARE HIGHLY ASSOCIATED WITH FLT3-ITD AND NPM1 MUTATIONS

Por Chen, Weina, Konoplev, Sergej, Medeiros, L. Jeffrey, Koeppen, Hartmut, Leventaki, Vasiliki, Vadhan-Raj, Saroj, Jones, Dan, Kantarjian, Hagop M., Falini, Brunangelo, Bueso-Ramos, Carlos E.
Publicado em 2009

Intratumoral characteristics of tumor and immune cells at baseline and on-treatment correlated with clinical responses to MPDL3280A, an engineered antibody against PD-L1

Por Kohrt, Holbrook, Kowanetz, Marcin, Gettinger, Scott, Powderly, John, Koeppen, Hartmut, Sosman, Jeffrey A, Cruz, Cristina, Xiao, Yuanyuan, Mokatrin, Ahmad, Fine, Gregg, Chen, Daniel S, Hodi, F Stephen
Publicado em 2013

Cytoplasmic Localization of Nucleophosmin in Bone Marrow Blasts of Acute Myeloid Leukemia Patients is not Completely Concordant with NPM1 Mutation and is not Predictive of Prognosi...

Por Konoplev, Sergej, Huang, Xuelin, Drabkin, Harry A., Koeppen, Hartmut, Jones, Dan, Kantarjian, Hagop M., Garcia-Manero, Guillermo, Chen, Weina, Weina, L. Jeffrey, Bueso-Ramos, Carlos E.
Publicado em 2009

TMEFF2 Is a PDGF-AA Binding Protein with Methylation-Associated Gene Silencing in Multiple Cancer Types Including Glioma

Por Lin, Kui, Taylor, James R., Wu, Thomas D., Gutierrez, Johnny, Elliott, J. Michael, Vernes, Jean-Michel, Koeppen, Hartmut, Phillips, Heidi S., de Sauvage, Frederic J., Meng, Y. Gloria
Publicado em 2011

MET Gene Copy Number Alterations and Expression of MET and Hepatocyte Growth Factor Are Potential Biomarkers in Angiosarcomas and Undifferentiated Pleomorphic Sarcomas

Por Schmitz, Katja, Koeppen, Hartmut, Binot, Elke, Fassunke, Jana, Künstlinger, Helen, Ihle, Michaela A., Heydt, Carina, Wardelmann, Eva, Büttner, Reinhard, Merkelbach-Bruse, Sabine, Rüschoff, Josef, Schildhaus, Hans-Ulrich
Publicado no PLoS One (2015)

Systems-wide Analysis of K-Ras, Cdc42, and PAK4 Signaling by Quantitative Phosphoproteomics

Por Gnad, Florian, Young, Amy, Zhou, Wei, Lyle, Karen, Ong, Christy C., Stokes, Matthew P., Silva, Jeffrey C., Belvin, Marcia, Friedman, Lori S., Koeppen, Hartmut, Minden, Audrey, Hoeflich, Klaus P.
Publicado em 2013

Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor

Por Deng, Rong, Bumbaca, Daniela, Pastuskovas, Cinthia V., Boswell, C. Andrew, West, David, Cowan, Kyra J., Chiu, Henry, McBride, Jacqueline, Johnson, Clarissa, Xin, Yan, Koeppen, Hartmut, Leabman, Maya, Iyer, Suhasini
Publicado no MAbs (2016)

Impact of Exploratory Biomarkers on the Treatment Effect of Bevacizumab in Metastatic Breast Cancer

Por Jubb, Adrian M., Miller, Kathy D., Rugo, Hope S., Harris, Adrian L., Chen, Dafeng, Reimann, James D., Cobleigh, Melody A., Schmidt, Maike, Langmuir, Virginia K., Hillan, Kenneth J., Chen, Daniel S., Koeppen, Hartmut
Publicado em 2011

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

Por Ong, Christy C., Jubb, Adrian M., Haverty, Peter M., Zhou, Wei, Tran, Victoria, Truong, Tom, Turley, Helen, O'Brien, Tom, Vucic, Domagoj, Harris, Adrian L., Belvin, Marcia, Friedman, Lori S., Blackwood, Elizabeth M., Koeppen, Hartmut, Hoeflich, Klaus P.
Publicado em 2011

A Phase II Randomized Trial (GO27827) of First‐Line FOLFOX Plus Bevacizumab with or Without the MET Inhibitor Onartuzumab in Patients with Metastatic Colorectal Cancer

Por Bendell, Johanna C., Hochster, Howard, Hart, Lowell L., Firdaus, Irfan, Mace, Joseph R., McFarlane, Joshua J., Kozloff, Mark, Catenacci, Daniel, Hsu, Jessie J., Hack, Stephen P., Shames, David S., Phan, See‐Chun, Koeppen, Hartmut, Cohn, Allen L.
Publicado no Oncologist (2017)

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

Por Wilson, Timothy R., Fridlyand, Jane, Yan, Yibing, Penuel, Elicia, Burton, Luciana, Chan, Emily, Peng, Jing, Lin, Eva, Wang, Yulei, Sosman, Jeff, Ribas, Antoni, Li, Jiang, Moffat, John, Sutherlin, Daniel P., Koeppen, Hartmut, Merchant, Mark, Neve, Richard, Settleman, Jeff
Publicado em 2012

Targeted Biomarker Profiling of Matched Primary and Metastatic Estrogen Receptor Positive Breast Cancers

Por Schleifman, Erica B., Desai, Rupal, Spoerke, Jill M., Xiao, Yuanyuan, Wong, Cheryl, Abbas, Ilma, O’Brien, Carol, Patel, Rajesh, Sumiyoshi, Teiko, Fu, Ling, Tam, Rachel N., Koeppen, Hartmut, Wilson, Timothy R., Raja, Rajiv, Hampton, Garret M., Lackner, Mark R.
Publicado em 2014