Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

p21-activated kinases (PAKs) are serine/threonine protein kinases that serve as important mediators of Rac and Cdc42 GTPase function as well as pathways required for Ras-driven tumorigenesis. PAK1 has been implicated in signaling by growth factor receptors and morphogenetic processes that control ce...

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Detalhes bibliográficos
Main Authors: Ong, Christy C., Jubb, Adrian M., Haverty, Peter M., Zhou, Wei, Tran, Victoria, Truong, Tom, Turley, Helen, O'Brien, Tom, Vucic, Domagoj, Harris, Adrian L., Belvin, Marcia, Friedman, Lori S., Blackwood, Elizabeth M., Koeppen, Hartmut, Hoeflich, Klaus P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084065/
https://ncbi.nlm.nih.gov/pubmed/21482786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1103350108
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