PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition

Pancreatic adenocarcinoma (PDAC) is a major unmet medical need and a deeper understanding of molecular drivers is needed to advance therapeutic options for patients. We report here that p21-activated kinase 1 (PAK1) is a central node in PDAC cells downstream of multiple growth factor signalling path...

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Detalhes bibliográficos
Publicado no:J Pathol
Main Authors: Zhou, Wei, Jubb, Adrian M, Lyle, Karen, Xiao, Qian, Ong, Christy C, Desai, Rupal, Fu, Ling, Gnad, Florian, Song, Qinghua, Haverty, Peter M, Aust, Daniela, Grützmann, Robert, Romero, Mally, Totpal, Klara, Neve, Richard M, Yan, Yibing, Forrest, William F, Wang, Yulei, Raja, Rajiv, Pilarsky, Christian, de Jesus-Acosta, Ana, Belvin, Marcia, Friedman, Lori S, Merchant, Mark, Jaffee, Elizabeth M, Zheng, Lei, Koeppen, Hartmut, Hoeflich, Klaus P
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380185/
https://ncbi.nlm.nih.gov/pubmed/25074413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4412
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