Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

Although Akt is known as a survival kinase, inhibitors of the phosphatidylinositol 3-kinase (PI3K)–Akt pathway do not always induce substantial apoptosis. We show that silencing Akt1 alone, or any combination of Akt isoforms, can suppress the growth of tumors established from phosphatase and tensin...

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Bibliografiske detaljer
Main Authors: Degtyarev, Michael, De Mazière, Ann, Orr, Christine, Lin, Jie, Lee, Brian B., Tien, Janet Y., Prior, Wei W., van Dijk, Suzanne, Wu, Hong, Gray, Daniel C., Davis, David P., Stern, Howard M., Murray, Lesley J., Hoeflich, Klaus P., Klumperman, Judith, Friedman, Lori S., Lin, Kui
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2008
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2557046/
https://ncbi.nlm.nih.gov/pubmed/18838554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200801099
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