Targeting the Glucose Regulated Protein-78 (GRP78) abrogates Pten-null driven AKT-activation and endometrioid tumorigenesis

Rates of the most common gynecologic cancer, endometrioid adenocarcinoma (EAC), continue to rise, mirroring the global epidemic of obesity, a well-known EAC risk factor. Thus, identifying novel molecular targets to prevent and/or mitigate EAC is imperative. The prevalent Type 1 EAC commonly harbors...

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Udgivet i:Oncogene
Main Authors: Lin, Yvonne G., Shen, Jieli, Yoo, Eunjeong, Liu, Ren, Yen, Hai-Yun, Mehta, Arjun, Rajaei, Atefeh, Yang, Wangrong, Mhawech-Fauceglia, Paulette, DeMayo, Francesco J., Lydon, John, Gill, Parkash, Lee, Amy S.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537850/
https://ncbi.nlm.nih.gov/pubmed/25684138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.4
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