Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat

BACKGROUND: Significant under-prediction of in vivo clearance in rat was observed for a potent p21-activated kinase (PAK1) inhibitor, GNE1. OBJECTIVE: Rate-determining (rapid uptake) and rate-limiting (slow excretion) steps in systemic clearance and elimination of GNE1, respectively, were evaluated...

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Publicado no:Drug Metab Lett
Main Authors: Fan, Peter W., Chen, Jacob Z., Jaochico, M. Allan, La, Hank, Liu, Ning, Mulder, Teresa, Cass, Robert T., Durk, Matthew, Messick, Kirsten, Valle, Nicole, Liu, Shannon, Lee, Wendy, Crawford, James J., Rudolph, Joachim, Murray, Lesley J., Khojasteh, S. Cyrus, Wright, Matthew
Formato: Artigo
Idioma:Inglês
Publicado em: Bentham Science Publishers 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405622/
https://ncbi.nlm.nih.gov/pubmed/27063863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1872312810666160411144358
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