Targeting cancer with kinase inhibitors

מאת Gross, Stefan, Rahal, Rami, Stransky, Nicolas, Lengauer, Christoph, Hoeflich, Klaus P.
הוצא לאור ב J Clin Invest (2015)

Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells

מאת Arias-Romero, Luis E., Villamar-Cruz, Olga, Huang, Min, Hoeflich, Klaus P., Chernoff, Jonathan
יצא לאור 2013

p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway

מאת Radu, Maria, Lyle, Karen, Hoeflich, Klaus P., Villamar-Cruz, Olga, Koeppen, Hartmut, Chernoff, Jonathan
הוצא לאור ב Mol Cell Biol (2015)

FDG-PET is a good biomarker of both early response and acquired resistance in BRAF(V600) mutant melanomas treated with vemurafenib and the MEK inhibitor GDC-0973

מאת Baudy, Andreas R, Dogan, Taner, Flores-Mercado, Judith E, Hoeflich, Klaus P, Su, Fei, van Bruggen, Nicholas, Williams, Simon-Peter
יצא לאור 2012

Combined Targeting of BRAF and CRAF or BRAF and PI3K Effector Pathways Is Required for Efficacy in NRAS Mutant Tumors

מאת Jaiswal, Bijay S., Janakiraman, Vasantharajan, Kljavin, Noelyn M., Eastham-Anderson, Jeffrey, Cupp, James E., Liang, Yuxin, Davis, David P., Hoeflich, Klaus P., Seshagiri, Somasekar
יצא לאור 2009

p21-activated kinase 1: PAK'ed with potential

מאת Ong, Christy C., Jubb, Adrian M., Zhou, Wei, Haverty, Peter M., Harris, Adrian L., Belvin, Marcia, Friedman, Lori S., Koeppen, Hartmut, Hoeflich, Klaus P.
יצא לאור 2011

The PI3K inhibitor taselisib overcomes letrozole resistance in a breast cancer model expressing aromatase

מאת Hoeflich, Klaus P., Guan, Jane, Edgar, Kyle A., O'Brien, Carol, Savage, Heidi, Wilson, Timothy R., Neve, Richard M., Friedman, Lori S., Wallin, Jeffrey J.
הוצא לאור ב Genes Cancer (2016)

Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition

מאת Kirkpatrick, Donald S., Bustos, Daisy J., Dogan, Taner, Chan, Jocelyn, Phu, Lilian, Young, Amy, Friedman, Lori S., Belvin, Marcia, Song, Qinghua, Bakalarski, Corey E., Hoeflich, Klaus P.
יצא לאור 2013

<it>p</it>HUSH: a single vector system for conditional gene expression

מאת Eby Mike, Murray Lesley J, Gogineni Alvin, Gu Zhenyu, Peng Li, Hoeflich Klaus P, Gray Daniel C, Kljavin Noelyn, Seshagiri Somasekar, Cole Mary J, Davis David P
יצא לאור 2007-09-01

pHUSH: a single vector system for conditional gene expression

מאת Gray, Daniel C, Hoeflich, Klaus P, Peng, Li, Gu, Zhenyu, Gogineni, Alvin, Murray, Lesley J, Eby, Mike, Kljavin, Noelyn, Seshagiri, Somasekar, Cole, Mary J, Davis, David P
יצא לאור 2007

Systems-wide Analysis of K-Ras, Cdc42, and PAK4 Signaling by Quantitative Phosphoproteomics

מאת Gnad, Florian, Young, Amy, Zhou, Wei, Lyle, Karen, Ong, Christy C., Stokes, Matthew P., Silva, Jeffrey C., Belvin, Marcia, Friedman, Lori S., Koeppen, Hartmut, Minden, Audrey, Hoeflich, Klaus P.
יצא לאור 2013

Group I Paks as therapeutic targets in NF2-deficient meningioma

מאת Chow, Hoi-Yee, Dong, Biao, Duron, Sergio G., Campbell, David A., Ong, Christy C., Hoeflich, Klaus P., Chang, Long-Sheng, Welling, D. Bradley, Yang, Zeng-jie, Chernoff, Jonathan
הוצא לאור ב Oncotarget (2015)

Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle

מאת Dogan, Taner, Gnad, Florian, Chan, Jocelyn, Phu, Lilian, Young, Amy, Chen, Mark J., Doll, Sophia, Stokes, Matthew P., Belvin, Marcia, Friedman, Lori S., Kirkpatrick, Donald S., Hoeflich, Klaus P., Hatzivassiliou, Georgia
הוצא לאור ב J Biol Chem (2017)

Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series

מאת Rudolph, Joachim, Aliagas, Ignacio, Crawford, James J., Mathieu, Simon, Lee, Wendy, Chao, Qi, Dong, Ping, Rouge, Lionel, Wang, Weiru, Heise, Christopher, Murray, Lesley J., La, Hank, Liu, Yanzhou, Manning, Gerard, Diederich, François, Hoeflich, Klaus P.
הוצא לאור ב ACS Med Chem Lett (2015)

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

מאת Ong, Christy C., Jubb, Adrian M., Haverty, Peter M., Zhou, Wei, Tran, Victoria, Truong, Tom, Turley, Helen, O'Brien, Tom, Vucic, Domagoj, Harris, Adrian L., Belvin, Marcia, Friedman, Lori S., Blackwood, Elizabeth M., Koeppen, Hartmut, Hoeflich, Klaus P.
יצא לאור 2011

Multiplexed gene expression profiling identifies the FGFR4 pathway as a novel biomarker in intrahepatic cholangiocarcinoma

מאת Yoo, Changhoon, Kang, Jihoon, Kim, Deokhoon, Kim, Kyu-Pyo, Ryoo, Baek-Yeol, Hong, Seung-Mo, Hwang, Jung Jin, Jeong, Seong-Yun, Hwang, Shin, Kim, Ki-Hun, Lee, Young-Joo, Hoeflich, Klaus P., Schmidt-Kittler, Oleg, Miller, Stephen, Choi, Eun Kyung
הוצא לאור ב Oncotarget (2017)

Active PI3K Pathway Causes an Invasive Phenotype Which Can Be Reversed or Promoted by Blocking the Pathway at Divergent Nodes

מאת Wallin, Jeffrey J., Guan, Jane, Edgar, Kyle A., Zhou, Wei, Francis, Ross, Torres, Anthony C., Haverty, Peter M., Eastham-Anderson, Jeffrey, Arena, Sabrina, Bardelli, Alberto, Griffin, Sue, Goodall, John E., Grimshaw, Kyla M., Hoeflich, Klaus P., Torrance, Christopher, Belvin, Marcia, Friedman, Lori S.
יצא לאור 2012

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

מאת Degtyarev, Michael, De Mazière, Ann, Orr, Christine, Lin, Jie, Lee, Brian B., Tien, Janet Y., Prior, Wei W., van Dijk, Suzanne, Wu, Hong, Gray, Daniel C., Davis, David P., Stern, Howard M., Murray, Lesley J., Hoeflich, Klaus P., Klumperman, Judith, Friedman, Lori S., Lin, Kui
יצא לאור 2008

PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition

מאת Zhou, Wei, Jubb, Adrian M, Lyle, Karen, Xiao, Qian, Ong, Christy C, Desai, Rupal, Fu, Ling, Gnad, Florian, Song, Qinghua, Haverty, Peter M, Aust, Daniela, Grützmann, Robert, Romero, Mally, Totpal, Klara, Neve, Richard M, Yan, Yibing, Forrest, William F, Wang, Yulei, Raja, Rajiv, Pilarsky, Christian, de Jesus-Acosta, Ana, Belvin, Marcia, Friedman, Lori S, Merchant, Mark, Jaffee, Elizabeth M, Zheng, Lei, Koeppen, Hartmut, Hoeflich, Klaus P
הוצא לאור ב J Pathol (2014)

Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK(a) Polar Moiety

מאת Ndubaku, Chudi O., Crawford, James J., Drobnick, Joy, Aliagas, Ignacio, Campbell, David, Dong, Ping, Dornan, Laura M., Duron, Sergio, Epler, Jennifer, Gazzard, Lewis, Heise, Christopher E., Hoeflich, Klaus P., Jakubiak, Diana, La, Hank, Lee, Wendy, Lin, Baiwei, Lyssikatos, Joseph P., Maksimoska, Jasna, Marmorstein, Ronen, Murray, Lesley J., O’Brien, Thomas, Oh, Angela, Ramaswamy, Sreemathy, Wang, Weiru, Zhao, Xianrui, Zhong, Yu, Blackwood, Elizabeth, Rudolph, Joachim
הוצא לאור ב ACS Med Chem Lett (2015)