Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle

The interconnected PI3K and MAPK signaling pathways are commonly perturbed in cancer. Dual inhibition of these pathways by the small-molecule PI3K inhibitor pictilisib (GDC-0941) and the MEK inhibitor cobimetinib (GDC-0973) suppresses cell proliferation and induces cell death better than either sing...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Dogan, Taner, Gnad, Florian, Chan, Jocelyn, Phu, Lilian, Young, Amy, Chen, Mark J., Doll, Sophia, Stokes, Matthew P., Belvin, Marcia, Friedman, Lori S., Kirkpatrick, Donald S., Hoeflich, Klaus P., Hatzivassiliou, Georgia
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582827/
https://ncbi.nlm.nih.gov/pubmed/28655764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.792754
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