Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle

The interconnected PI3K and MAPK signaling pathways are commonly perturbed in cancer. Dual inhibition of these pathways by the small-molecule PI3K inhibitor pictilisib (GDC-0941) and the MEK inhibitor cobimetinib (GDC-0973) suppresses cell proliferation and induces cell death better than either sing...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Dogan, Taner, Gnad, Florian, Chan, Jocelyn, Phu, Lilian, Young, Amy, Chen, Mark J., Doll, Sophia, Stokes, Matthew P., Belvin, Marcia, Friedman, Lori S., Kirkpatrick, Donald S., Hoeflich, Klaus P., Hatzivassiliou, Georgia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2017
Konular:
Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582827/
https://ncbi.nlm.nih.gov/pubmed/28655764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.792754
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